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Home > Hormone Reset > Thyrotonin for Better Sleep, No Matter Your Thyroid Symptoms

Thyrotonin for Better Sleep, No Matter Your Thyroid Symptoms

While I’m not always confident in my naming abilities, I think this one came out alright: It’s a combination of ‘thyroid’ and ‘melatonin.’ The reason they are combined is that this supplement can help not only your sleep patterns, but your thyroid, too.

Simply put, tiny amounts of melatonin, in supplement form, can be a good thing. It can improve sleep, regulate immunity, and reduce free radicals. However, many of these benefits go out the window when the dose is too high. When it comes to thyroid-induced sleep issues, you have to keep it small and sweet.

So, how much is too much, and how does this thyroid specific formulation help you? Here’s all the information I wrote for the product monograph of Thyrotonin.

Product Recommendation: Thyrotonin is a Doctor Formulated Melatonin that has shown significant improvements in thyroid function. Both T4 and T3 levels improved by elevating from their baseline readings. Click Here

Table of Contents

Thyroid Disease & Dyssomnias
Introducing Thyrotonin
What Are The Benefits Of Thyrotonin?
How Do You Take Thyrotonin?
How Do We Select Thyroid Specific Formulation Ingredients?
Thyrotonin: Ingredients Breakdown
How Should You Take Thyrotonin?
Thyrotonin: Cautions
Resources

Thyroid Disease & Dyssomnias

What is a dyssomnia? Quite simply it refers to the collection of sleep disorders that negatively impact the quantity and quality of sleep. These include forms of:

  • Nighttime insomnia
  • Daytime sleepiness
  • Exaggerated sleep requirements

The truth is that both hypothyroidism and hyperthyroidism can increase the likelihood of dyssomnias1.

How does that happen? Well, it turns out that the thyroid gland itself is a source of melatonin2. Studies have shown that endogenous melatonin may play immunoregulatory roles that prevent autoimmune diseases such as Hashimoto’s Thyroiditis3.

Among those with thyroid disease, dyssomnias contribute to symptoms including:

  • Fatigue
  • Brain fog
  • Weight gain
  • Increased appetite4
  • Chronic pain5
  • Irritable bowel symptoms6

Does Melatonin Supplementation Help?

Melatonin is the pituitary hormone, largely responsible for your daily sleep cycle. When taken orally, it increases serum melatonin levels similar to the body’s own increase in the night.

Invivo studies have shown melatonin supplementation to have paradoxical effects on thyroid disease. In physiologic amounts it may be protective, but in pharmacologic doses it may worsen autoimmune reactions7.

Melatonin exerts its effects when it is absorbed by MT1 and MT2 receptors in the brain. When levels of melatonin in the blood are higher than physiologically normal, this receptor activity diminishes giving melatonin a biphasic response.

Hence, the results of high-dose melatonin may be lower than the results of low-dose melatonin.

Key Insight: In fact, high-dose melatonin can even diminish the response to the body’s own melatonin8.

This inhibitory effect is more pronounced on adults over 40. In fact, older adults may show the strongest response to melatonin doses in the range of 100-200 mcg9. Yet most commercial melatonin products range in potency from 1-5 mg.

What Is Sustained & Immediate Release?

Many popular melatonin products use binding agents to achieve a sustained release effect (a more consistent release over a longer period of time). The rationale is that doing so will mimic the body’s same secretion of melatonin throughout the course of the evening.

Yet, pharmacokinetic studies have shown that immediate release and sustained release melatonin yield the same response over the course of the evening.

Moreover, sustained release has the disadvantage of staying in the bloodstream in the daytime, possibly contributing to feeling fatigued throughout the day10.

Bottom Line: When it comes to melatonin, you need to have it in the right amounts. Because, even if you are taking it, it may be worsening your thyroid symptoms and it may be the exact thing preventing you from getting a good night’s sleep.

Introducing Thyrotonin

For all of the reasons above, I knew that there had to be a better way to supplement melatonin — specifically for those struggling with thyroid disease.

What I came up with, as part of an entire line of thyroid specific formulations, is Thyrotonin. A supplement that offers the opportunity to do right by your thyroid and your sleep schedule.

What Are The Benefits Of Thyrotonin?

The ingredients found in Thyrotonin have been clinically proven to:

  • Decrease sleep onset
  • Improve sleep duration
  • Improve symptoms associated with jet lag

How Do You Take Thyrotonin?

All you have to do is take one pill at bedtime and away from food. You should use Thyrotonin in conjunction with any medical treatment for acute or chronic dyssomnia.

How Do We Select Thyroid Specific Formulation Ingredients?

This is important. In this case, every single ingredient considered must share the following properties to warrant inclusion…

Thyroid Safety

All considered ingredients must be natural compounds that have been safely consumed by humans for centuries. They must be generally recognized as safe (GRAS) by toxicologists. Finally, they must not contain unsafe levels of iodine.

Evidence & Efficacy

All considered ingredients must have high-quality evidence proving their efficacy. The best quality evidence is that which demonstrates significant positive outcomes, on human subjects, in multiple, double-blinded controlled studies.

Ultimately, these human subjects and the outcomes should be clinically relevant to the product’s end-users. It needs to mean something for them.

Thyrotonin: Ingredients Breakdown

The following is a complete discussion of the active ingredients that can be found in Thyrotonin. It includes their relevance to thyroid disease, their mechanisms of action, and a review of the supportive research…

Microdose Melatonin

What’s the difference between melatonin and microdose melatonin? It’s all in the amounts! Microdose melatonin can be found in amounts measured in mcg, rather than mg.

In fact, in a clinical study, melatonin or placebo was given at nighttime to a group of perimenopausal and postmenopausal women for six months total.

Those taking low-dose melatonin showed significant improvements in thyroid function. Both T4 and T3 levels improved by elevating from their baseline readings11.

In other studies, high-dose melatonin showed no such beneficial effects on thyroid function12.

The women taking melatonin in the above study also showed an improvement in the secretion of gonadal hormones including estradiol and testosterone.

Melatonin supplementation moved women toward hormonal equilibrium even when they started out differently. The perimenopausal women ages 43-49 saw a beneficial lowering of LH and no changes to FSH. The postmenopausal women ages 50-62 saw a beneficial lowering of FSH.

Participants noted a corresponding decrease of depression and menopausal symptoms.

Key Insight: That’s why microdose melatonin is so important, because you can see real benefits when you keep the dosage low and intentional.

If you just take more and more, it may get in the way of feeling good in the morning (as well as not helping with other symptoms).

How Should You Take Thyrotonin?

Consider taking one to three capsules, at bedtime, away from food.

What Doesn’t Thyrotonin Contain?

Thyrotonin does not contain any of the following:

  • Caffeine
  • Stimulants
  • Thyroid hormones
  • Iodine
  • GMO
  • Gluten
  • Dairy

Thyrotonin: Cautions

The ingredients listed have not been studied in pregnant or lactating women and should be avoided.

Those on thyroid medication may need a reduction in their dosage due to the usage of this product. Please work with your prescriber to monitor your thyroid levels regularly and report any new symptoms or changes to existing symptoms.

Try Thyrotonin Today

Now that you know a bit more about it, how about trying it for yourself? If you’re interested in handling thyroid symptoms while achieving better sleep, then Thyrotonin may be perfect for you.

Resources

1 – Wickboldt AT, Bowen AF, Kaye AJ, Kaye AM, Rivera Bueno F, Kaye AD. Sleep physiology, abnormal States, and therapeutic interventions. Ochsner J. 2012;12(2):122-134.
2 – Acuña-Castroviejo D, Escames G, Venegas C, Díaz-Casado ME, Lima-Cabello E, López LC, Rosales-Corral S, Tan DX, Reiter RJ. Extrapineal melatonin: sources, regulation, and potential functions. Cell Mol Life Sci. 2014 Aug;71(16):2997-3025. doi: 10.1007/s00018-014-1579-2. Epub 2014 Feb 20. PMID: 24554058.
3 – A possible mechanism for altered immune response in the elderly.
Mazzoccoli G, DE Cata A, Carughi S, Greco A, Inglese M, Perfetto F, Tarquini R
In Vivo. 2010 Jul-Aug; 24(4):471-87.
4 – Geiker NRW, Astrup A, Hjorth MF, Sjödin A, Pijls L, Markus CR. Does stress influence sleep patterns, food intake, weight gain, abdominal obesity and weight loss interventions and vice versa? Obes Rev. 2018 Jan;19(1):81-97. doi: 10.1111/obr.12603. Epub 2017 Aug 28. PMID: 28849612.
5 – Haack M, Simpson N, Sethna N, Kaur S, Mullington J. Sleep deficiency and chronic pain: potential underlying mechanisms and clinical implications. Neuropsychopharmacology. 2020 Jan;45(1):205-216. doi: 10.1038/s41386-019-0439-z. Epub 2019 Jun 17. PMID: 31207606; PMCID: PMC6879497.
6 – Wang B, Duan R, Duan L. Prevalence of sleep disorder in irritable bowel syndrome: A systematic review with meta-analysis. Saudi J Gastroenterol. 2018 May-Jun;24(3):141-150. doi: 10.4103/sjg.SJG_603_17. PMID: 29652034; PMCID: PMC5985632.
7 – Lin, JD., Fang, WF., Tang, KT. et al. Effects of exogenous melatonin on clinical and pathological features of a human thyroglobulin-induced experimental autoimmune thyroiditis mouse model. Sci Rep 9, 5886 (2019). https://doi.org/10.1038/s41598-019-42442-0
8 – Witt-Enderby PA, Bennett, J, Jarzynka, MJ, et al., Melatonin receptors and their regulation. Biochemical and structural mechanisms, Life Sci, 2003;72:2183–98.
9 – Low Doses of Melatonin Promote Sleep Onset and Maintenance in Older People—An Update – touchNEUROLOGY. https://touchneurology.com/alzheimers-disease-dementia/journal-articles/low-doses-of-melatonin-promote-sleep-onset-and-maintenance-in-older-people-an-update/. Accessed May 28, 2021.
10 – Gooneratne NS, Edwards AY, Zhou C, Cuellar N, Grandner MA, Barrett JS. Melatonin pharmacokinetics following two different oral surge-sustained release doses in older adults. J Pineal Res. 2012;52(4):437-445. doi:10.1111/j.1600-079X.2011.00958.x
11 – Bellipanni G, Bianchi P, Pierpaoli W, Bulian D, Ilyia E. Effects of melatonin in perimenopausal and menopausal women: a randomized and placebo controlled study. Exp Gerontol. 2001 Feb;36(2):297-310. doi: 10.1016/s0531-5565(00)00217-5. PMID: 11226744.
12 – D’Anna R, Santamaria A, Giorgianni G, Vaiarelli A, Gullo G, Di Bari F, Benvenga S. Myo-inositol and melatonin in the menopausal transition. Gynecol Endocrinol. 2017 Apr;33(4):279-282. doi: 10.1080/09513590.2016.1254613. Epub 2016 Dec 2. PMID: 27910708.

P.S. Whenever you are ready, here is how I can help you now:

1. Schedule a Thyroid Second Opinion with me, Dr. C, Click Here for Details
2. Need A Thyroid Supplement Recommendation? Take My Thyroid Specific Formulations Quiz Now
3. Need a Personalized Supplement? Check out My Thyroid Specific Formulations
4. Download and use my Favorite Recipes Cookbook Here
5. Check out my podcast Medical Myths, Legends, and Fairytales Here

Dr. Alan Glen Christianson (Dr. C) is a Naturopathic Endocrinologist and the author of The NY Times bestselling Adrenal Reset Diet, The Metabolism Reset Diet and The Thyroid Reset Diet.

Dr. C’s gift for figuring out what really works has helped hundreds of thousands of people reverse thyroid disease, lose weight, diabetes, and regain energy. Learn more about the surprising story that started his quest.

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